Hi Pseudoephedrine is effective, and shown to have less cardiovascular and central nervous system effects than ephedrine as a nasal decongestant.
The recommended maximum dose (for adults) is 60mg per 4 hours (usual dose is 60mg per 6 hours). As for the doubling of the dose, I would agree with your pharmacist (putting my healthcare hat on). The half life of pseudoephedrine in the plasma is 5-8 hours. But it is noteworthy that the elimination of pseudoephedrine from the body is facilitated by acidic urine - so I would recommend some Vitamin C drink (which helps acidify the urine) or cranberry juice (which also makes the urine more acidic). Excitement, restlessness, rapid speech are possible symptoms of overdoasge - so watch out for this.
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timeasmymeasure
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Date: 2001-09-21 04:31 am (UTC)The recommended maximum dose (for adults) is 60mg per 4 hours (usual dose is 60mg per 6 hours). As for the doubling of the dose, I would agree with your pharmacist (putting my healthcare hat on). The half life of pseudoephedrine in the plasma is 5-8 hours. But it is noteworthy that the elimination of pseudoephedrine from the body is facilitated by acidic urine - so I would recommend some Vitamin C drink (which helps acidify the urine) or cranberry juice (which also makes the urine more acidic). Excitement, restlessness, rapid speech are possible symptoms of overdoasge - so watch out for this.